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| 八肽胆囊收缩素对吗啡抑制大鼠离体空肠电与收缩活动的对抗作用 | |
| 作者姓名： | Xu MY Yang DX Wang SZ Jin HB Zou XH Yang XP Han JS |
| 作者单位： | 1. 哈尔滨医科大学生理教研室,哈尔滨,150086 2. 上海黄浦区中心医院外科,上海,200002 3. 北京医科大学生理教研室,北京,100083 |
| 基金项目： | 黑龙江省教育委员会科学技术基金!95-8 |
| 摘 要： | 本研究探讨了八肽胆囊收缩素（ＣＣＫ－８）对抗吗啡对大鼠离体空肠电与收缩活动的作用。结果表明,吗啡能抑制ＡＣｈ对空肠峰波发放和收缩的加强作用;ＣＣＫ－８可对抗吗啡的作用;在此基础上,ＣＣＫ－Ａ受体拮抗剂ｄｅｖａｚｅｐｉｄｅ（１０ｎｍｏｌ／Ｌ）能完全翻转ＣＣＫ－８的抗吗啡作用,但是ＣＣＫ－Ｂ受体拮抗剂Ｌ－３６５,２６０在１０ｎｍｏｌ／Ｌ时可部分翻转、在３０ｎｍｏｌ／Ｌ时能完全翻转ＣＣＫ－８的作用。上述 |
| 关 键 词： | 八肽胆囊收缩素 CCK受体 空肠 电活动 收缩 |
Antagonistic effect of CCK-8 on morphine-inhibited electrical and contractile activities of rat jejunum in vitro |
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| Xu MY,Yang DX,Wang SZ,Jin HB,Zou XH,Yang XP,Han JS.Antagonistic effect of CCK-8 on morphine-inhibited electrical and contractile activities of rat jejunum in vitro[J].Acta Physiologica Sinica,1998,50(4):469-473. | |
| Authors: | Xu M Y Yang D X Wang S Z Jin H B Zou X H Yang X P Han J S |
| Institution: | Department of Physiology, Harbin Medical University, Harbin 150086. |
| Abstract: | in the present investigation, antagonistic action of cholecystokinin octapeptide (CCK-8)against morphine on the electrical and contractile activity of rat jejunum in vitro was studied. The results showed that the potentiation of acetylcholine (ACh) on both the burst of spike and the contractility were inhibited by morphine, which could be complete angagonized by CCK-8. The CCK-8 effect, again, could be suppressed by CCX-A receptor antagonist devazepide (10mol/L), but partially by CCX-B receptor antagonist L-365,260 at 10 nmol/L or completely at concentration of 30 mol/L. The above results demonstrated that the antagonism of CCK-8 on morphine was mediated by both CCK-A and CCK-B receptors. |
| Keywords: | cholecystokinin octapeptide cholecystokinin receptor antagonist jejunum electrical activity contraction |
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