A fight for neurotransmission: SCRAPPER trashes RIM |
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| Authors: | Dobie Frederick Craig Ann Marie |
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| Affiliation: | Brain Research Centre, Department of Psychiatry, University of British Columbia, Vancouver, BC, V6T 2B5, Canada. |
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| Abstract: | The presynaptic scaffold molecule RIM1alpha is important for regulating neurotransmitter release. In this issue, Yao et al. (2007) show in mice that an E3 ubiquitin ligase, SCRAPPER, targets a set of presynaptic proteins including RIM1alpha for degradation by the ubiquitin-proteasome system. Their results identify protein degradation as a mechanism for holding rapid synaptic communication in check. |
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