Elevated levels of serum antibodies against alpha-1, 6-glucan in patients with systemic lupus erythematosus or rheumatoid arthritis |
| |
Authors: | Hui Dai Xiao-Ming Gao |
| |
Institution: | 1. Department of Immunology, Peking University Health Science Center, Peking University, Beijing 100083, China; 2. Institute of Biology and Medical Sciences, Soochow University, Suzhou 215123, China |
| |
Abstract: | This study was undertaken to investigate whether levels of anti-alpha-1, 6-glucan antibodies in human sera correlate with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Serum samples were collected from patients with SLE (n = 30), RA (n = 30) and healthy adult volunteers. IgG, IgA and IgM levels against alpha-1, 6-glucan were measured using enzyme linked immunosorbent assays. Anti-alpha-1, 6-glucan IgG prevalence was raised in patients with active SLE (73.3%) and RA (60%) compared with healthy controls (13.3%). Strong correlation between anti-alpha-1,6-glucan-IgG levels and anti-perinuclear factor (r = 0.642; p<0.05) in RA patients or anti-nuclear antibodies (r = 0.675; p<0.05) in SLE patients was observed. No significant differences in anti-alpha-1,6-glucan-IgA or-IgM levels were noted between different groups. We conclude that anti-alpha-1,6-glucan-IgG levels were significantly elevated in patients with SLE or RA and positively correlated with disease activity. |
| |
Keywords: | autoantibody anti-alpha-1 6-glucan autoimmune diseases systemic lupus erythematosus rheumatoid arthritis |
|
| 点击此处可从《蛋白质与细胞》浏览原始摘要信息 |
| 点击此处可从《蛋白质与细胞》下载免费的PDF全文 |
|