SP110 polymorphisms are not associated with pulmonary tuberculosis in a South African population |
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| Authors: | C. Babb E. Hanekom Keet P. D. van Helden E. G. Hoal |
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| Affiliation: | (1) Molecular Biology and Human Genetics, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, MRC Centre for Molecular and Cellular Biology, Faculty of Health Sciences, Stellenbosch University, P.O. Box 19063, Tygerberg, 7505 Cape Town, South Africa |
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| Abstract: | Susceptibility to tuberculosis (TB) in mice has recently been attributed to the Ipr1 gene. Polymorphisms in the human homologue, SP110, have been investigated in various populations with only one study finding an association with TB susceptibility. We investigated eight SP110 polymorphisms in a South African population, including two novel polymorphisms. No significant association was found with any of the polymorphisms investigated, including two polymorphisms that were previously found to be associated with TB susceptibility in West African populations. |
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