Structure-activity relationship of 5'-substituted fluoro-neplanocin a analogues as potent inhibitors of S-adenosylhomocysteine hydrolase |
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| Authors: | Moon Hyung Ryong Lee Kang Man Lee Joo Hyun Lee Sang Kook Park Seung Bin Chun Moon Woo Jeong Lak Shin |
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| Institution: | College of Pharmacy, Pusan National University, Pusan 609-735, Korea. |
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| Abstract: | Four 5'-substituted fluoro-neplanocin A analogues la-d were designed and synthesized, and the inhibitory activity against SAH was in the following order: NH2 > SH > F, N3, indicating a hydrogen bonding donor is essential for inhibitory activity. |
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