Riboflavin analogs utilized for metabolism by a Lactobacillus casei mutant |
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| Authors: | J P Lambooy |
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| Affiliation: | 1. Department of Biochemistry and Molecular Biology and Immunology (B), Faculty of Chemistry, University of Murcia, Campus of Espinardo, Regional Campus of International Excellence “Campus Mare Nostrum”, P.O. Box 4021, Murcia E-30100, Spain;2. Laboratory of Bioinorganic Chemistry, University of Bologna, Department of Pharmacy and Biotechnology, Via Giuseppe Fanin 40, I-40127 Bologna, Italy |
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| Abstract: | Several new halogen-containing riboflavin analogs that are antagonists for the stock strain of Lactobacillus casei have been found to be utilized by a mutant strain of the microorganism for growth and acid production. Riboflavin analogs consisting of all combinations of a single aliphatic group (methyl or ethyl) and a single halogen group (chloro or bromo) in positions 7 and 8 of the isoalloxazine nucleus possess this property. The analog devoid of substituents in positions 7 and 8 and the analog possessing a methyl group in position 7 and a cysteinyl group in position 8, were inert for both strains of the microorganism. |
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