Endomorphin-1, an endogenous mu-opioid receptor-selective agonist, stimulates oxygen consumption in mice. |
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| Authors: | A Asakawa A Inui N Ueno M Fujimiya M A Fujino M Kasuga |
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| Affiliation: | Second Department of Internal Medicine, Kobe University School of Medicine, Japan. |
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| Abstract: | This study was undertaken to investigate the effect of endogenous mu-receptor-selective peptide endomorphin 1, administered intracerebroventricularly, on oxygen consumption in mice. The intracerebroventricular injection of endomorphin 1 (3-30 nmol) significantly increased oxygen consumption in unrestrained mice. The effect of endomorphin 1 (30 nmol) was significantly antagonized by the simultaneous intraperitoneal administration of naloxone (100 nmol). These results suggest that endomorphin 1 stimulates oxygen consumption, and that the mu-opioid receptor influences energy balance in mice. |
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