Vasoactive intestinal polypeptide: release into hypophyseal portal blood. |
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| Authors: | S I Said J C Porter |
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| Affiliation: | 1. Veterans Administration Medical Center Dallas, Texas 75216, USA;2. Departments of Internal Medicine, Pharmacology, Obstetrics & Gynecology, and Physiology University of Texas Southwestern Medical School Dallas, Texas 75235, USA |
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| Abstract: | Immunoreactive vasoactive intestinal polypeptide (VIP) was present in portal hypophyseal blood of 24 male rats in concentrations (mean, 995 pg per ml) that were approximately 19 times as high as those in systemic arterial blood (mean, 52 pg per ml). The results demonstrate release of VIP from the hypothalamic-neurohypophyseal complex into the portal circulation, and establish a mechanism for direct influence of the peptide on pituitary function. |
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