Expression of a New Complement-fixing Antigen reactive with Murine Sarcoma Virus Rat Antiserum in Rat Cells transformed by Polyoma Virus |
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| Authors: | JOHNG S RHIM C R LENGEL H Y CHO K K TAKEMOTO H C TURNER R J HUEBNER R V GILDEN |
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| Institution: | 1.Microbiological Associates, Inc., National Institutes of Allergy and Infectious Diseases and National Cancer Institute, National Institutes of Health,Bethesda;2.Flow Laboratories, Inc.,Rockville |
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| Abstract: | WE reported accelerated transformation by DNA viruses (SV40 and polyoma) in rat embryo (RE) cells chronically infected with a C-type RNA virus1,2. Recently we found in RE cells transformed by polyoma virus a new complement-fixing (CF) antigen detectable by rat antisera having broad reactivity with the various intraspecies and interspecies antigens of the RNA tumour viruses3–8; this antigen, however, was distinct from the murine intraspecies and interspecies group-specific (gs) antigens both immunologically and by virtue of other properties. It is also distinct from the polyoma virion (capsid) and tumour (“T”) antigens. |
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