Increased survival and neuroprotective effects of BN82451 in a transgenic mouse model of Huntington's disease |
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Authors: | Klivenyi Peter Ferrante Robert J Gardian Gabrielle Browne Susan Chabrier Pierre-Etienne Beal M Flint |
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Institution: | Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York 10021, USA. |
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Abstract: | There is substantial evidence that excitotoxicity and oxidative damage may contribute to Huntington's disease (HD) pathogenesis. We examined whether the novel anti-oxidant compound BN82451 exerts neuroprotective effects in the R6/2 transgenic mouse model of HD. Oral administration of BN82451 significantly improved motor performance and improved survival by 15%. Oral administration of BN82451 significantly reduced gross brain atrophy, neuronal atrophy and the number of neuronal intranuclear inclusions at 90 days of age. These findings provide evidence that novel anti-oxidants such as BN82451 may be useful for treating HD. |
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Keywords: | experimental therapeutics huntington inflammation neurodegeneration oxidative damage transgenic mice |
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