Designed inhibitors of horse liver alcohol dehydrogenase. Effect of active-site metal ion substitution |
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| Authors: | C Freudenreich U Pfangert M Weis M Zeppezauer J F Biellmann |
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| Affiliation: | 1. Laboratoire de Chimie Organique Biologique, Institut de Chimie, UA 31, Université Louis Pasteur, 1 Rue Biaise Pascal, 67008 Strasbourg, France;2. Fachbereich 15, Fachrichtung 15.2 - Biochemie, Universität des Saarlandes, 6600 Saarbrücken, FRG |
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| Abstract: | 3-(p-Butoxyphenyl)propionamide, -thioamide and -hydrazide and the formamide of p-butoxybenzylamine were tested as inhibitors of cadmium(II) and cobalt(II) active-site substituted alcohol dehydrogenase. The results agree with a direct coordination of these inhibitors except for the hydrazide to the active-site metal ion, in the enzyme-NADH-inhibitor complex. The hydrazide might be situated at some distance from the metal ion without a direct coordination bond. |
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