Biological activities of lipopolysaccharide of Burkholderia (Pseudomonas) pseudomallei |
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| Authors: | Motohiro Matsuura Kazuyoshi Kawahara Takayuki Ezaki masayasu Nakano |
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| Affiliation: | Department of Microbiology, Jichi Medical School, 3311-1 Yakushiji, Minamikawachi-machi, Tochigi 329-04, Japan; Department of Bacteriology, The Kitasato Institute, Shirokane, Minato-ku, Tokyo 108, Japan; Department of Microbiology, Gifu University School of Medicine, Gifu, Gifu 500, Japan |
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| Abstract: | Abstract Endotoxic activities of lipopolysaccharide (LPS) isolated from Burkholderia (Pseudomonas) pseudomallei , a causative agent of melioidosis, were investigated. Compared to an enterobacterial LPS (SAE-LPS), B. pseudomallei LPS (BP-LPS) exhibited weaker pyrogenic activity in rabbits, lethal toxicity in galactosamine-sensitized mice and murine macrophage activation, i.e. production of tumor necrosis factor, interleukin-6 and nitric oxide. BP-LPS, on the other hand, exhibited stronger mitogenic activity to murine splenocytes than SAE-LPS; moreover, it stimulated even the splenocytes of LPS-resistant C3H/HeJ mice. Unusual chemical structures in the acid-stable inner core region attached to the lipid A moiety of BP-LPS may be responsible for this strong mitogenic activity. |
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| Keywords: | Burkholderia pseudomallei Pseudomonas pseudomallei Lipopolysaccharide Endotoxin |
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