Influence of semax on the emotional state of white rats in the norm and against the background of cholecystokinin-tetrapeptide action |
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Authors: | N G Levitskaya D A Vilenskii E A Sebentsova L A Andreeva A A Kamensky N F Myasoedov |
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Institution: | (1) Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Nussbaumstr. 7, 80336 Munich, Germany;(2) Exploratory Clinical Development, Novartis Pharma AG, Basel, Switzerland;(3) Biostatistics, Novartis Pharma AG, Basel, Switzerland;(4) Harrison Clinical Research Institute, Munich, Germany |
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Abstract: | The effects of the adrenocorticotropic hormone (ACTH(4–10)) analog, Semax (MEHFPGP), on the level of anxiety and depression
in white rats have been studied in the normal state and against the back-ground of cholecystokinin-tetrapeptide (CCK-4) action.
Semax was injected intranasally in doses of 50 and 500 μg/kg 15 min before the testing. CCK-4 was administered intraperitoneally
in a dose of 400 μg/kg 40 min before the testing. The level of anxiety was estimated in the elevated plus-maze test, and the
degree of depression, in the forced swimming test. Semax administration did not influence the emotional state of animals in
the normal state. The CCK-4 injection led to an increase in anxiety and depression in rats. Semax normalized the animal behavior
disturbed by the CCK-4 administration, which attests to its anxiolytic and antidepressant effects at elevated levels of anxiety
and depression. |
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