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The gene encoding the Ia-Associated invariant chain is located on chromosome 18 in the mouse |
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| Authors: | Kazuhiko Yamamoto Georgia Floyd-Smith Uta Francke Norbert Koch Wolfgang Lauer Bernhard Dobberstein Reinhold Schäfer Günter J Hämmerling |
| Institution: | (1) Institute of Immunology and Genetics, German Cancer Research Center, D-6900 Heidelberg, Germany;(2) Department of Human Genetics, Yale University School of Medicine, 06510 New Haven, Connecticut;(3) European Molecular Biology Laboratory, D-6900 Heidelberg, Germany;(4) Institut für Zellbiologie, Universitätsklinikum, Essen, D-4300 Essen, Germany |
| Abstract: | The chromosomal assignment of the gene encoding the invariant (Ii) chain associated with the mouse immune response antigens (la) was determined by Southern blot analysis of DNA from a panel of mouse x Chinese hamster somatic cell hybrids cleaved with Hind III or Eco RI. Using a mouse Ii cDNA as a hybridization probe, we localized the gene coding for the invariant chain to mouse chromosome 18. |
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