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肝脏特异性miR-122的分子生物学特性及功能
引用本文:徐洁,吴福生,蔡荣.肝脏特异性miR-122的分子生物学特性及功能[J].生物物理学报,2009,25(3):183-191.
作者姓名:徐洁  吴福生  蔡荣
作者单位:1. 浙江大学医学院附属第一医院,杭州310003;
2. 浙江理工大学生命科学学院,杭州310018
基金项目:863国家高技术研究发展计划项目(2008AA02Z109), 浙江省自然科学基金项目(Y2080304)
摘    要:miR-122是在肝脏特异高表达的一种microRNA。研究表明:生理状态下,miR-122 在调控肝脏的细胞发育、诱导细胞分化、调节细胞代谢、参与肝细胞应急应答等生命活动过程中发挥重要作用;而在病理状态下,miR-122 与丙型肝炎病毒(HCV)和肝细胞肝癌(HCC)密切相关,可能促进HCV RNA 复制,并在HCC发生、发展过程中发挥抑癌基因样作用,可能对HCC 临床诊断和预后具有重要价值。鉴于miR-122 参与调控肝脏生理及肝脏重大疾病的发生、发展等过程,文章详细阐述并讨论miR-122 在肝脏中的生物学特性和功能,以及可能的作用机制。肝脏特异性miR-122 有可能作为治疗人类肝脏疾病的关键靶点。

关 键 词:miR-122  hcr  阳离子氨基酸转运体-1  丙型肝炎病毒  肝细胞肝癌
收稿时间:2008-10-31
修稿时间:2009-04-29

The Characteristics and Functions of Molecular Biology for Liver-specific miR-122
Abstract:miR-122 is specifically and abundantly expressed in the human liver. The recent investigations have demonstrated that under the physiological condition, miR-122 may play important roles in regulating hepatocyte development, differentiation, metabolism, stress responses, and under the pathological condition, the abnormal expression of miR-122 is closely related to hepatitis C virus (HCV) or hepatocellular carcinoma (HCC), and miR-122 is likely to facilitate replication of HCV RNA or is as a tumor suppressor gene for hepatocarcinogenesis. In addition, miR-122 could have diagnostic and prognostic significance for HCC. Respecting the effects of miR-122 on the major diseases of the human liver, the authors reviewed and analyzed the biological characteristics, diverse functions and possible mechanisms of miR-122. This liver-specific microRNA, miR-122, could be exploited as a key target for the treatment of human liver diseases.
Keywords:miR-122  hcr  CAT-1  HCV  HCC
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