Normal Range of Hepatic Fat Fraction on Dual- and Triple-Echo Fat Quantification MR in Children |
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| Authors: | Hyun Joo Shin Hyun Gi Kim Myung-Joon Kim Hong Koh Ha Yan Kim Yun Ho Roh Mi-Jung Lee |
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| Institution: | 1Department of Radiology and Research Institute of Radiological Science, Severance Children’s Hospital, Yonsei University College of Medicine, Seoul, Korea;2Department of Pediatrics, Severance Children’s Hospital, Yonsei University College of Medicine, Seoul, Korea;3Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Korea;The Chinese University of Hong Kong, HONG KONG |
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| Abstract: | ObjectivesTo evaluate hepatic fat fraction on dual- and triple-echo gradient-recalled echo MRI sequences in healthy children.ResultsIn 54 children (M:F = 26:28; 5–15 years; mean 9 years), the dual fat fraction (0.1–8.0%; median 1.6%) was not different from the triple fat fraction (0.4–6.5%; median 2.7%) (p = 0.010). The dual- and triple-echo fat fractions showed good agreement using a Bland-Altman plot (-0.6 ± 2.8%). Eight children (14.8%) on dual-echo sequences and six (11.1%) on triple-echo sequences had greater than 5% fat fraction. From these children, six out of eight children on dual-echo sequences and four out of six children on triple-echo sequences had a 5–6% hepatic fat fraction. When using a cut-off value of a 6% fat fraction derived from a reference interval, only 3.7% of children were diagnosed with fatty liver. There was no significant correlation between clinical and laboratory findings with dual and triple-echo fat fractions.ConclusionsDual fat fraction was not different from triple fat fraction. We suggest a cut-off value of a 6% fat fraction is more appropriate for diagnosing fatty liver on both dual- and triple-echo sequences in children. |
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