|
|||||
|
|
Effects of garlic oil on tumoragenecity and intercellular communication in human gastric cancer cell line |
|
| Authors: | LI Xiaoguang XIE Jinyu LI Wenmei JI Jiafu CUI Jiantao ZHAO Min SUN Mei L Youyong |
| Institution: | 1. China Rehabilitation Research Center,Beijing 100077,China 2. China Academy of Traditional Chinese Medicine,Beijing 100700,China 3. Beijing Institute for Cancer Research,The School of Oncology,Beijing Medical University,Beijing 100034,China |
| Abstract: | Previous studies have demonstrated that garlic oil (GO) and its anti-tumor compound could inhibit DNA and RNA synthesis in human cancer cells.In order to explore the effects of garlic oil on carcinoma cells,a gastric carcinoma cell line,BGC-823 was studied at cellular and molecular levels after garlic oil treatment.Data showed that the cell differentiation and suppression of tumorigenicity were significantly induced in tumor cells after garlic oil treatment.There was a correlation between the cell-cell communication recovery and the increase of p53 and waf1/p21 gene expression in garlic oil-treated cells.This result suggested that tumor suppressor gene waf1/p21 and wt p53 might play an important role in this effect. |
| Keywords: | waf1/p21 garlic oil gastric cancer cell communication |
| 本文献已被 万方数据 SpringerLink 等数据库收录！ | |