Serological survey of T-lymphocyte differentiation antigens in wild mice |
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| Authors: | Yasuyuki Kurihara Nobumoto Miyashita Kazuo Moriwaki Michael L. Petras François Bonhomme Wang Su Cho Sei-ichi Kohno |
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| Affiliation: | (1) Department of Cell Genetics, National Institute of Genetics, 411 Mishima, Shizuoka, Japan;(2) Department of Biology, University of Windsor, Windsor, Ontario, Canada;(3) Institut des Sciences de l'Evolution, Université des Sciences et Techniques du Languedoc, Montpellier, France;(4) Institute of Agricultural Sciences, 170 Suweon, Republic of Korea;(5) Department of Biology, Faculty of Science, University of Toho, Funabashi, Chiba, Japan;(6) National Institute of Genetics, Yata l, 141, Mishima, 411 Shizuoka, Japan |
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| Abstract: | Allelic distributions of Thy-1, Ly-l, and Ly-2 antigens in wild mice are characteristic of each Mus musculus subspecies. Eastern mice (M.m.molossinus, M.mmusculus, M.m.castaneus, M.m.bactrianus) express the Thy-1.1 antigen, whereas Western mice (M.m. domesticus, M.m.brevirostris) express the Thy-1.2. All mice from wild populations examined in this survey express the Ly-1.2. The Ly-2.1 is distributed in Eastern mice and some Western mice, and the Ly-2.2 is found in the remaining Western mice. Allelic distributions of these antigens were also examined in two other species, Mus spretus and Mus spicilegus. Allelic constitutions of Thy-1 and Ly-1 in these species are similar to those of Eastern mice. Some M.spicilegus, however, express the Ly-1.1 antigen. This antigenic type is not found in M.musculus. Some Eastern mice related to M.m.castaneus react weakly to Ly-1.2-specific and Ly-2.1-specific monoclonal antibodies in both the complement-mediated cytotoxicity test and the absorption test. These results suggest that M.m.castaneus has unique alleles in the Ly-1 and Ly-2 loci. |
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