Progress in the rational design of an AIDS vaccine |
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| Authors: | Nabel Gary J Kwong Peter D Mascola John R |
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| Institution: | Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, MSC 3005, Bethesda, MD 20892, USA. gnabel@mail.nih.gov |
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| Abstract: | Human immunodeficiency virus-1 (HIV-1) has a high degree of genetic and antigenic diversity that has impeded the development of an effective vaccine using traditional methods. We are attempting to develop an AIDS vaccine by employing strategies that include structural biology and computational modelling, in an effort to develop immunogens capable of eliciting neutralizing antibodies of the requisite breadth and potency against circulating strains of HIV-1. |
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| Keywords: | HIV-1 vaccine design informatics structural biology antibody response computational techniques |
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