Polymorphic variants of genes involved in homocysteine metabolism in celiac disease |
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Authors: | Kamil K Hozyasz Adrianna Mostowska Anna Szaflarska-Poplawska Margarita Lianeri Pawel P Jagodzinski |
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Institution: | (1) Department of Pediatrics, Institute of Mother and Child, 17a Kasprzaka Street, 01-211 Warsaw, Poland;(2) Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznan, Poland;(3) Department of Pediatrics, Allergology and Gastroenterology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Bydgoszcz, Poland |
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Abstract: | Celiac disease (CD) is a polygenic chronic enteropathy conferring an increased risk for various nutrient deficiency states.
Hyperhomocysteinemia is a frequent finding in CD and may be related to the development of venous thrombosis, cardiovascular
disease, and stroke in untreated CD patients. Recently, a possible excess in the frequency of the MTHFR c.677C>T (rs1801133) gene variant in CD patients was reported. The purpose of this study was to determine if there exist
differences in the distribution of polymorphic variants of genes involved in homocysteine/methyl group metabolism between
CD patients and the general population. A set of 10 gene polymorphisms (MTHFR rs1801133, MTR rs1805087, MTHFD1 rs2236225, MTRR rs1801394, CBS 844ins68, BHMT1 rs7356530 and rs3733890, BHMT2 rs526264 and rs625879, and TCN2 rs1801198) was tested in 134 patients with CD and 160 matched healthy controls. The frequency of the MTR rs1805087 GG genotype in CD patients was lower than in controls (0.01 and 0.06, respectively), although statistical significance
was not achieved (P = 0.06). For the other analyzed polymorphisms, there was no evidence of difference in both allelic and genotypic distribution
between cases and controls. The exhaustive Multifactor Dimensionality Reduction analysis revealed no combination of interactive
polymorphisms predicting the incidence of CD. In contrast to the well-documented clinical observations of increased risks
of vascular disease in patients with longstanding untreated CD, in our group of patients no significant association with CD
was found for all tested polymorphic variants of genes involved in homocysteine metabolism. These findings should be replicated
in studies with a larger sample size. |
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