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Zebrafish disease models in hematology: Highlights on biological and translational impact |
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| Authors: | Daniela Zizioli Marina Mione Marco Varinelli Michele Malagola Simona Bernardi Elisa Alghisi Giuseppe Borsani Dario Finazzi Eugenio Monti Marco Presta Domenico Russo |
| Institution: | 1. Unit of Biotechnology, Department of Molecular and Translational Medicine, University of Brescia, Italy;2. CIBIO, Center for Integrative Biology, University of Trento, Italy;3. Unit of Blood Disease and Stem Cell Transplantation, Department of Clinical and Experimental Sciences, University of Brescia, ASST-Spedali Civili di Brescia, Italy;4. Unit of Biology and Genetic, Department of Molecular and Translational Medicine, University of Brescia, Italy;5. Clinical Chemistry Laboratory, ASST, Spedali Civili di Brescia, Italy;6. Unit of Oncology and Immunology, Department of Molecular and Translational Medicine, University of Brescia, Italy |
| Abstract: | Zebrafish (Danio rerio) has proven to be a versatile and reliable in vivo experimental model to study human hematopoiesis and hematological malignancies. As vertebrates, zebrafish has significant anatomical and biological similarities to humans, including the hematopoietic system. The powerful genome editing and genome-wide forward genetic screening tools have generated models that recapitulate human malignant hematopoietic pathologies in zebrafish and unravel cellular mechanisms involved in these diseases. Moreover, the use of zebrafish models in large-scale chemical screens has allowed the identification of new molecular targets and the design of alternative therapies. In this review we summarize the recent achievements in hematological research that highlight the power of the zebrafish model for discovery of new therapeutic molecules. We believe that the model is ready to give an immediate translational impact into the clinic. |
| Keywords: | Zebrafish Hematopoiesis Leukemia models Xenotransplantation Chemical screens |
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