Interferon suppresses glutamine synthetase induction in chick embryonic neural retina. |
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| Authors: | T Matsuno N Shirasawa S Kohno |
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| Institution: | 1. The Russell Grimwade School of Biochemistry, Melbourne University, Parkville, Victoria, 3052, Australia;2. The Department of Molecular Biology, Vanderbilt University, Tennessee, 37235, U.S.A. |
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| Abstract: | Two different proteins precipitable with antiserum to albumin exist in liver. One is albumin, the other is precursor albumin. Liver cells in suspension contain mainly precursor, but secrete only albumin. In subcellular fractions isolated from liver homogenate, 95.3% of anti-albumin precipitable protein in the rough endoplasmic reticulum, 51.4% in the smooth endoplasmic reticulum, 33.5% in the Golgi apparatus and 0% in the supernatant fraction was precursor albumin. The results suggest that albumin precursor is synthesized in the rough endoplasmic reticulum and converted into albumin in the smooth endoplasmic reticulum and the Golgi apparatus. |
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