Transcellular transactivation by the human immunodeficiency virus type 1 tat protein. |
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| Authors: | D E Helland J L Welles A Caputo W A Haseltine |
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| Affiliation: | Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115. |
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| Abstract: | The human immunodeficiency virus type 1 (HIV-1) transactivator (tat) protein produced in one cell activated HIV-1 promoter-directed gene expression in a second cell, provided the cells were in direct contact with one another. This observation suggests that the tat protein produced in HIV-1-infected cells has a physiological effect on neighboring cells. |
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