Acute effects of carbon monoxide on the metabolism of perfused rat liver |
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| Authors: | David L. Topping |
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| Affiliation: | Department of Cardiovascular Pharmacology, Tobacco Research Council Laboratories, Otley Road, Harrogate, North Yorkshire HG3 1PY, U.K. |
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| Abstract: | 1. Perfusion of livers with whole blood containing carboxyhaemoglobin decreased hepatic O(2) consumption and triglyceride secretion and raised free fatty acid oxidation. 2. Perfusion with [(14)C]carboxyhaemoglobin indicated that there was negligible hepatic uptake of (14)CO. 3. The observations appear to be due to a decrease in O(2) consumption rather than to specific effects of carboxyhaemoglobin. |
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