Functional,genetic and bioinformatic characterization of a calcium/calmodulin kinase gene in <Emphasis Type="Italic">Sporothrix schenckii</Emphasis> |
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| Authors: | Liz Valle-Aviles Shirley Valentin-Berrios Ricardo R Gonzalez-Mendez Nuri Rodriguez-del Valle |
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| Institution: | (1) Department of Microbiology and Medical Zoology, Medical Sciences Campus, University of Puerto Rico, San Juan, PR PO Box 365067, 00936-5067, USA;(2) Department of Microbiology, San Juan Bautista School of Medicine, Caguas, PR Box 4968, 00726-4968, USA;(3) Department of Radiological Sciences, Medical Sciences Campus, University of Puerto Rico, San Juan, PR PO Box 365067, 00936-5067, USA |
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| Abstract: | Background
Sporothrix schenckiiis a pathogenic, dimorphic fungus, the etiological agent of sporotrichosis, a subcutaneous lymphatic mycosis. Dimorphism inS. schenckiiresponds to second messengers such as cAMP and calcium, suggesting the possible involvement of a calcium/calmodulin kinase
in its regulation. In this study we describe a novel calcium/calmodulin-dependent protein kinase gene inS. schenckii, sscmk1, and the effects of inhibitors of calmodulin and calcium/calmodulin kinases on the yeast to mycelium transition and the yeast
cell cycle. |
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