The Fer tyrosine kinase regulates an axon retraction response to Semaphorin 3A in dorsal root ganglion neurons |
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| Authors: | Zoya Shapovalova Kyrylo Tabunshchyk Peter A Greer |
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| Institution: | (1) Division of Cancer Biology and Genetics, Queen's University Cancer Research Institute, Kingston, Ontario, K7L 3N6, Canada;(2) Department of Pathology and Molecular Medicine, , Kingston, Ontario, Canada;(3) Department of Mechanical Engineering, University of Alberta and National Institute for Nanotechnology, NRC, Alberta, Canada;(4) NASU, Lviv, Institute for Condensed Matter Physics, 79011, Ukraine |
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| Abstract: | Background Fps/Fes and Fer are the only two members of a distinct subclass of cytoplasmic protein tyrosine kinases. Fps/Fes was previously
implicated in Semaphorin 3A (Sema3A)-induced growth cone collapse signaling in neurons from the dorsal root ganglion (DRG)
through interaction with and phosphorylation of the Sema3A receptor component PlexinA1, and members of the collapsin response
mediator protein (CRMP) family of microtubule regulators. However, the potential role of the closely related Fer kinase has
not been examined. |
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