The evolutionary history of mitochondrial porins |
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| Authors: | Matthew J Young Denice C Bay Georg Hausner Deborah A Court |
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| Affiliation: | (1) Department of Microbiology, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada |
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| Abstract: | Background Mitochondrial porins, or voltage-dependent anion-selective channels (VDAC) allow the passage of small molecules across the mitochondrial outer membrane, and are involved in complex interactions regulating organellar and cellular metabolism. Numerous organisms possess multiple porin isoforms, and initial studies indicated an intriguing evolutionary history for these proteins and the genes that encode them. |
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