家畜抗性等级性状的QTL定位方法

在广义线性模型的框架内模拟研究了家畜抗性等级性状的QTL定位方法，QTL参数的估计采用最大似然方法，比较了阈模型方法与一般线性方法的QTL定位效率，并对影响等级性状QTL定位效率的主要因素（QTL效应、性状的遗传力）进行了模拟研究，实验设计为多个家系的女儿设计，资源群体大小为500头。研究结果表明：在QTL位置参数估计及检验功效方面，阈模型方法具有一定的优势，对抗性等级性状QTL定位的功效也高于线性方法。另外，性状遗传力和QTL效应的大小对QTL定位的准确度也有直接的影响，随着性状遗传力QTL效应的

Methodology of Mapping Quantitative Trait Loci for Ordinal Traits of Disease Resistance in Livestock

Methodology of QTL mapping for ordinal traits of di sease resistance based on the framework of a generalized linear model (GLM) was presented.The location and effect parameters of putative QTL were estimated usin g maximum likelihood method.The efficiency and power were compared with the line ar model (LM).The factors influencing QTL detection efficiency (e.g.QTL effect a nd heritability) were simulated in our study too.Daughter design with multiple f amilies was applied,and the number of segregating population was 500.Results sho wed that the threshold model has a certain advantage in location estimation and power of QTL mapping,and has efficiency and accuracy for ordinal traits.In addit ion,the accuracy of QTL mapping depends on the effect of putative quantitative t rait loci and the value of heritability.With the increase of QTL effect and heri tability,the accuracy of QTL mapping improves slightly.