IFN-gamma receptor-Ig fusion proteins. Half-life, immunogenicity, and in vivo activity. |
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Authors: | C Kürschner L Ozmen G Garotta Z Dembic |
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Affiliation: | Department of Biology, F. Hoffmann-La Roche Ltd., Basel, Switzerland. |
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Abstract: | Two mouse IFN-gamma receptor (MoIFN gamma R)-Ig fusion proteins, which were constructed for the purpose of creating new efficient mouse IFN-gamma (MoIFN-gamma) inhibitor molecules, were studied in vivo to determine their plasma half-life and immunogenicity, and to show their biologic activity. The hybrid proteins show 40-h blood persistency. They do not provoke an antibody response when injected into mice, and they are biologically active in vivo, as demonstrated by the prevention of streptozotocin-induced diabetes. The two fusion proteins are efficient MoIFN-gamma antagonists and can be used in mouse models of human diseases to investigate the role of MoIFN gamma in these pathologic states. |
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