The vascular endothelium as a target tissue in acute cadmium toxicity |
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| Authors: | C V Nolan Z A Shaikh |
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| Affiliation: | 1. UMR 8638 CNRS COMETE, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Pharmacie, 4 avenue de l''Observatoire, 75006 Paris, France;2. Fondation PremUp, 4 avenue de l''Observatoire, 75014 Paris, France;3. INSERM U1139, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Pharmacie, 4 avenue de l''Observatoire, 75006 Paris, France;1. Institute of Animal Molecular Biotechnology, Korea University, Seoul 02841, Republic of Korea;2. Department of Biomedical Sciences, Catholic Kwandong University, Gangneung 25601, Republic of Korea;3. Center for Animal Biotechnology and Genomics, Texas A&M University, College Station, TX 77843-2471, USA;4. Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea;5. Department of Animal Science, Texas A&M University, College Station, TX 77843-2471, USA |
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| Abstract: | Sensitivity of tissues to the acute toxicity of cadmium is reviewed. It is concluded that the initial effect of acute cadmium administration is on the integrity and permeability of the vascular endothelium; other necrotic changes occur secondarily to this effect. In a sensitive tissue, not all of the endothelial cells are susceptible to cadmium. Furthermore, after necrosis of the sensitive cells, the resistant cells proliferate and result in regeneration of the vasculature and subsequent acquired resistance to the metal. It is found that sex hormones are probably important in determining susceptibility and response of tissues to cadmium. The role of metallothionein in these phenomena remains to be elucidated. |
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