Dietary fructose vs glucose lowers copper solubility in the digesta in the small intestine of rats |
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Authors: | Gerrit J Van den Berg Shiguang Yu Annet Van der Heijden Arnoldina G Lemmens Anton C Beynen |
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Institution: | (1) Interfaculty Reactor Institute, Delft University of Technology, Delft, The Netherlands;(2) Department of Human Nutrition, Agricultural University, Wageningen, The Netherlands;(3) Department of Laboratory Animal Science, State University, Utrecht, The Netherlands |
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Abstract: | The hypothesis was tested that dietary fructose vs glucose lowers copper solubility in the digesta in the small intestine
of rats, which in turn causes a decreased copper absorption. Male rats were fed adequate-copper (5 mg Cu/kg) diets containing
either fructose or glucose (709.4 g monosaccharide/kg) for a period of 5 wk. Fructose vs glucose significantly lowered copper
concentrations in plasma and the liver, but did not alter hepatic copper mass. Fructose feeding resulted in a significantly
lesser intestinal solubility of copper as based on either a smaller soluble fraction of copper in the liquid phase of small
intestinal contents or a lower copper concentration in the liquid phase. The latter fructose effect can be explained by the
observed fructose-induced increase in volume of liquid phase of intestinal digesta. After administration of a restricted amount
of diet extrinsically labeled with64Cu, rats fed fructose also had significantly lower soluble64Cu fraction in the digesta of the small intestine. Although this study shows that fructose lowered intestinal copper solubility,
only a slight reduction of apparent copper absorption was observed. It is suggested that the fructose-induced lowering of
copper status in part counteracted the fructose effect on copper absorption at the level of the intestinal lumen. |
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Keywords: | Rat dietary fructose copper absorption intestinal copper solubility |
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