Effect of chronic clonidine treatment on urinary growth hormone excretion and linear growth in children with short stature |
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| Authors: | A Sanmartí A Lucas M L Granada I Salinas J L Reverter J M Cuatrecasas M Foz L Audi |
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| Institution: | Endocrinology Section, Hospital Germans Trias i Pujol, Badalona, Spain. |
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| Abstract: | Eleven prepubertal children with short stature were treated with clonidine (0.15 mg/m2 daily) for a period of 1 year. The effect of this drug was evaluated on both clinical (growth velocity, height standard deviation scores for chronological age and bone age) and hormonal (urinary growth hormone excretion and insulin-like growth factor I) parameters. Our study shows that long-term clonidine administration in children with short stature did not result in significant differences in growth velocity, height standard deviation scores for chronological age and bone age, insulin-like growth factor I or in urinary growth hormone excretion. |
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