Effect of N-alkyl-N,N,N-trimethylammonium ions on phosphatidylcholine model membrane structure as studied by 31P-NMR |
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Authors: | P Balgavý K Gawrisch H Frischleder |
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Institution: | 1. Faculty of Pharmacy and Institute of Physics and Biophysics, J.A. Comenius University, 832 32 Bratislava Czechoslovakia;2. Section of Physics, Karl Marx University, 7010 Leipzig G.D.R. |
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Abstract: | The interaction of |CnH2n+1N+(CH3)3| · I? (n = 3, 6, 9, 12, 14, 16 or 18) with egg-yolk phosphatidylcholine-water dispersions has been studied by 31P-NMR spectroscopy. It is shown that the effective anisotropy of 31P chemical shift (?Δσeff) of the lamellar phospholipid liquid-crystalline phase Lα increases with increasing concentration and alkyl chain length of the drug. Addition of or |C9H19N+(CH3)3|·I? to the phospholipid-water dispersion at a molar ratio ammonium salt:phospholipid > 0.8 induces in the dispersion a structure with an effective isotropic phospholipid motion. This structure is unstable and slowly transforms into the hexagonal phase. These effects have not been observed in phospholipid-water dispersions mixed with the ammonium derivatives with the longer alkyl chains n 12, 14, 16 or 18. It is proposed that these results might explain the effects of the investigated drugs on the nerve, muscle and bacterial cells. |
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Keywords: | Alkylammonium ion Phosphatidylcholine Lipid polymorphism (Model membrane) TMA trimethylammonium TEA triethylammonium PC phosphatidylcholine DPPC dipalmitoylphosphatidylcholine |
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