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Effect of N-alkyl-N,N,N-trimethylammonium ions on phosphatidylcholine model membrane structure as studied by 31P-NMR
Authors:P Balgavý  K Gawrisch  H Frischleder
Institution:1. Faculty of Pharmacy and Institute of Physics and Biophysics, J.A. Comenius University, 832 32 Bratislava Czechoslovakia;2. Section of Physics, Karl Marx University, 7010 Leipzig G.D.R.
Abstract:The interaction of |CnH2n+1N+(CH3)3| · I? (n = 3, 6, 9, 12, 14, 16 or 18) with egg-yolk phosphatidylcholine-water dispersions has been studied by 31P-NMR spectroscopy. It is shown that the effective anisotropy of 31P chemical shift (?Δσeff) of the lamellar phospholipid liquid-crystalline phase Lα increases with increasing concentration and alkyl chain length of the drug. Addition of |C6H13N+(CH3)3| ·I ? or |C9H19N+(CH3)3I? to the phospholipid-water dispersion at a molar ratio ammonium salt:phospholipid > 0.8 induces in the dispersion a structure with an effective isotropic phospholipid motion. This structure is unstable and slowly transforms into the hexagonal phase. These effects have not been observed in phospholipid-water dispersions mixed with the ammonium derivatives with the longer alkyl chains n  12, 14, 16 or 18. It is proposed that these results might explain the effects of the investigated drugs on the nerve, muscle and bacterial cells.
Keywords:Alkylammonium ion  Phosphatidylcholine  Lipid polymorphism  (Model membrane)  TMA  trimethylammonium  TEA  triethylammonium  PC  phosphatidylcholine  DPPC  dipalmitoylphosphatidylcholine
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