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Rotational dynamics of immunoglobulins with fluorescent haptens on a membrane surface |
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| Authors: | Hiroshi Osada Mamoru Nakanishi Masamichi Tsuboi Kazuhiko Kinosita Akira Ikegami |
| Affiliation: | 1. Faculty of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113 Japan;2. The Institute of Physical and Chemical Research, Wako, Saitama 351 Japan |
| Abstract: | The rotational dynamics of rabbit immunoglobulin G with fluorescent lipid haptens on a membrane surface has been studied by nanosecond fluorescence emission anisotropic spectroscopy. It has been found that the rotational angles of the antibody are very restricted on the membrane, but that the rotation rate itself is not appreciably lower than that in solution, and is independent of the membrane fluidity. |
| Keywords: | Rotational dynamics Immunoglobulin Fluorescence anisotropy Lipid hapten Membrane fluidity (Liposome) 1,5-AEDANS To whom correspondence should be addressed. |
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