Rabbit skeletal alpha-tropomyosin chains are in register. |
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Authors: | F Johnson L B Smillie |
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Affiliation: | Laboratoire de Biochimie Structurale, U.E.R. de Sciences Fondamentales et Appliquées, 45045 Orléans Cédex France;Institut de Biochimie, Université de Paris-Sud, Centre d''Orsay, 91405 OrsayFrance |
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Abstract: | 2-Acetamido-2-deoxy-3-O-(D-2-propionyl-L-alanine)-D-glucopyranose () and 2-acetamido-2-deoxy-3-O-(D-2-propionyl-L-alanyl-D-isoglutamine)-D-glucopyranose () have been synthesized by condensation of benzyl 2-acetamido-4,6-O-benzylidene-3-O-(D-1-carboxyethyl)-2-deoxy-β-D-glucopyranoside () respectively with the L-alanine derivative and the dipeptide , followed by debenzylidenation and hydrogenolysis. Compound is adjuvant active, whereas is inactive, so that is the smallest adjuvant active structure for the time being. |
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