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Rabbit skeletal alpha-tropomyosin chains are in register.
Authors:F Johnson  L B Smillie
Affiliation:Laboratoire de Biochimie Structurale, U.E.R. de Sciences Fondamentales et Appliquées, 45045 Orléans Cédex France;Institut de Biochimie, Université de Paris-Sud, Centre d''Orsay, 91405 OrsayFrance
Abstract:2-Acetamido-2-deoxy-3-O-(D-2-propionyl-L-alanine)-D-glucopyranose (5) and 2-acetamido-2-deoxy-3-O-(D-2-propionyl-L-alanyl-D-isoglutamine)-D-glucopyranose (10) have been synthesized by condensation of benzyl 2-acetamido-4,6-O-benzylidene-3-O-(D-1-carboxyethyl)-2-deoxy-β-D-glucopyranoside (1) respectively with the L-alanine derivative 2 and the dipeptide 7, followed by debenzylidenation and hydrogenolysis. Compound 10 is adjuvant active, whereas 5 is inactive, so that 10 is the smallest adjuvant active structure for the time being.
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