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Novel terpenoids from Calocedrus macrolepis var. formosana
Authors:Hsieh Chin-Lin  Tseng Mei-Hwei  Pan Ryh-Nan  Chang Jang-Yang  Kuo Ching-Chuan  Lee Tzong-Huei  Kuo Yueh-Hsiung
Institution:Department of Chemistry, National Taiwan University, Taipei 106, Taiwan.
Abstract:Calocetriol ( 1 ), diacetylcalocediol ( 2 ), and ferrugimenthenol ( 3 ) were isolated from the bark of Calocedrus macrolepis var. formosana. Among them, 1 and 2 are secoabietane‐type diterpenoids, and 3 , with a novel C20 C10 skeleton, is classified as a meroterpenoid. The structures of 1 – 3 were elucidated by spectroscopic analyses, and their biological activities were also evaluated. Compound 3 exhibited significant cytotoxic activity against human oral epidermoid carcinoma KB cells with an IC50 value of 9.0±0.1 μM .
Keywords:Calocedrus macrolepis var  formosana  Secoabietanes  Diterpenoids  Meroterpenoids  Calocetriol  Diacetylcalocetriol  Ferrugimenthenol  Cytotoxic activity
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