Sesquiterpenoids and lignans from the roots of Valeriana officinalis L |
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| Authors: | Wang Peng-Cheng Ran Xin-Hui Chen Rui Luo Huai-Rong Ma Qing-Yun Liu Yu-Qing Hu Jiang-Miao Huang Sheng-Zhuo Jiang He-Zhong Chen Zhong-Quan Zhou Jun Zhao You-Xing |
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| Affiliation: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, P.?R. China, (phone: +086‐871‐5223264;2. fax: +086‐871‐5223261);3. Graduate School of the Chinese Academy of Sciences, Beijing, 100039, P.?R. China;4. Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou, 571101, P.?R. China |
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| Abstract: | Two new guaiane-type sesquiterpenoids, valerol A (1) and kessyl 3-acetate (2), together with nine known compounds, valeracetate (3), anismol A (4), orientalol C (5), spatulenol (6), 4α,10α-epoxyaromadendrane (7), (+)-8-hydroxypinoresinol (8), pinorespiol (9), pinoresinol 4-O-β-D-glucopyranoside (10), and 8-hydroxypinoresinol 4'-O-β-D-glucopyranoside (11) were isolated from the roots of Valeriana officinalis. The structures and relative configurations of 1 and 2 were elucidated on the basis of spectroscopic methods (1D- and 2D-NMR, MS, UV, and IR). These compounds were evaluated for inhibitory activity on acetylcholinesterase (AChE) and enhancing activity on nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells. |
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| Keywords: | Valeriana officinalis Sequiterpenoids Guaianes Inhibitors Acetylcholinesterase inhibition Valerol A Kessyl 3‐acetate |
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