Synthesis, characterization, thermal behavior, and DNA-cleaving studies of cyano-bridged nickel(II)-copper(II) complexes of 4-(pyridin-2-ylazenyl)resorcinol |
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Authors: | Karipcin Fatma Ozmen Ismail Cülü Burcin Celikoğlu Umut |
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Affiliation: | 1. Department of Chemistry, Sciences and Arts Faculty, Nev?ehir University, TR‐50300, Nev?ehir, (phone: +90?384?2153900;2. fax: +90?384?2153948);3. Department of Chemistry, Sciences and Arts Faculty, Süleyman Demirel University, TR‐32260, Isparta |
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Abstract: | We present here the syntheses of a mononuclear CuII complex and two polynuclear CuII NiII complexes of the azenyl ligand, 4‐(pyridin‐2‐ylazenyl)resorcinol (HL; 1). The reaction of HL ( 1 ) and copper(II) perchlorate with KCN gave a mononuclear complex [CuL(CN)] ( 4 ). Using 4 , one pentanuclear complex, [{CuL(NC)}4Ni](ClO4)2 ( 5 ) and one trinuclear complex, [{CuL(CN)}2NiL]ClO4 ( 6 ), were prepared and characterized by elemental analyses, magnetic susceptibility, molar conductance, IR, and thermal analysis. Stoichiometric and spectral results of the mononuclear CuII complex indicated that the metal/ligand/CN ratio was 1 : 1 : 1, and the ligand behaved as a tridentate ligand forming neutral metal chelates through the pyridinyl and azenyl N‐, and resorcinol O‐atom. The interaction between the compounds (the ligand 1 , its NiII and CuII complexes without CN, i.e., 2 and 3 , and its complexes with CN, 4 – 6 ) and DNA has also been investigated by agarose gel electrophoresis. The pentanuclear Cu4Ni complex ( 5 ) with H2O2 as a co‐oxidant exhibited the strongest DNA‐cleaving activity. |
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Keywords: | Resorcinol, 4‐(pyridin‐2‐ylazenyl)‐ Azo dyes Cyano bridges DNA Nickel complexes Copper complexes |
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