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The stimulation of macrophage prostaglandin E2 and thromboxane B2 secretion by Streptococcus mutans insoluble glucans |
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| Authors: | Y Abiko Y Shibata K Fukushima S Murai H Takiguchi |
| Institution: | 1. Department of Biochemistry, Nihon University School of Dentistry at Matsudo, 2-870-1, Sakaecho-Nishi, Matsudo, Chiba 271, Japan;2. Department of Microbiology, Nihon University School of Dentistry at Matsudo, 2-870-1, Sakaecho-Nishi, Matsudo, Chiba 271, Japan;3. Department of Conservative Dentistry, Nihon University School of Dentistry, 1-8-13, Kanda-Surugadai, Chiyoda-Ku, Tokoyo 101, Japan |
| Abstract: | The effect of insoluble glucan synthesized by Streptococcus mutans on 3H]arachidonate metabolites secretion from peritoneal macrophages was studied. Insoluble glucans stimulated 3H]arachidonate release and secretion of prostaglandin E2 and thromboxane B2 from macrophages. In contrast, commercial soluble glucan (dextran) did not induce 3H]arachidonate release. |
| Keywords: | AA arachidonic acid |
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