Institution: | a Department of Medicinal Chemistry, Preclinical Research & Development, Astra Draco AB, P O Box 34, S-211 00 Lund Sweden b Department of Pharmacology, Preclincial Research & Development, Astra Draco AB, P O Box 34, S-221 00 Lund Sweden c Department of Toxicology, Karolinska Institute, Box 60 400, S-104 01 Stockholm, Sweden d Department of Organic Chemistry, Royal Institute of Technology, S-100 44 Stockholm, Sweden |
Abstract: | 4,4′-Disubstituted dirayl tellurides showed glutathione peroxidase-like catalysis of the reduction of hydroperoxides by glutathione. The most potent compound, bis(4-aminophenyl) telluride, demonstrated 348%, 530%, 995% and 900% of the catalytic efficacy of Ebselen for the glutathione dependent reduction of H2O2, t-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide, respectively. |