A fast and sensitive multiple sequence alignment algorithm |
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| Authors: | Vingron, Martin Argos, Patrick |
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| Affiliation: | European Molecular Biology Laboratory Postfach 10.2209, Meyerhofstrasse I, 6900 Heidelberg, FRG |
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| Abstract: | A two-step multiple alignment strategy is presented that allowsrapid alignment of a set of homologous sequences and comparisonof pre-aligned groups of sequences. Examples are given demonstratingthe improvement in the quality of alignments when comparingentire groups instead of single sequences. The modular designof computer programs based on this algorithm allows for storageof aligned sequences and successive alignment of any numberof sequences. Received on August 23, 1988; accepted on December 6, 1988 |
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