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Polymorphic markers <Emphasis Type="Italic">Val762Ala</Emphasis> and <Emphasis Type="Italic">Leu54Phe</Emphasis> of the <Emphasis Type="Italic">ADPRT1</Emphasis> gene associated with chronic glomerulonephritis in Russian patients from Moscow |
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| Authors: | A E Shestakov E S Kamyshova E K Petrosyan I M Kutyrina K V Savostyanov V V Nosikov |
| Institution: | (1) Research Institute for Genetics and Selection of Industrial Microorganisms, Moscow, 117545, Russia;(2) Nephrology Division, Research Center and Department of Nephrology and Hemodialysis, Sechenov Medical Academy, Moscow, 119992, Russia;(3) Pediatric Hospital Chair, Russian State Medical University, Moscow, 117997, Russia |
| Abstract: | A comparative analysis of allele and genotype distribution of polymorphic markers Val762Ala and Leu54Phe of ADPRT1 gene encoding poly(ADP-ribose)polymerase1 has been performed in chronic glomerulonephritis patients compared to normal controls. This has shown a significant difference in the ADPRT1 gene polymorphic marker Val762Ala allele and genotype frequency distribution between chronic glomerulonephritis patients and healthy controls (according to Fisher’s exact test). At the same time the allele and genotype frequency for a polymorphic marker Leu54Phe distribution did not show significant difference between these groups. Therefore, we have concluded that the ADPRT1 gene polymorphic marker Val762Ala is associated with the development of chronic glomerulonephritis in Russian patients of the Moscow region. |
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