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Solid-phase synthesis and anti-infective activity of a combinatorial library based on the natural product anisomycin |
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| Authors: | Shi Shuhao Zhu Shirong Gerritz Samuel W Esposito Kim Padmanabha Ramesh Li Wenying Herbst John J Wong Henry Shu Yue Zhong Lam Kin S Sofia Michael J |
| Affiliation: | New Leads Chemistry, 5 Research Parkway, Wallingford, CT 06492, USA. shij@bms.com |
| Abstract: | The solid-phase synthesis of a library based on the natural product anisomycin is described. The resulting library was tested against a panel of bacterial and fungal targets, and active compounds were identified in a Staphylococcus aureus whole-cell assay and an efflux-deficient fungal whole-cell assay. |
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