Microbial transformation of 5alpha,6alpha-epoxy-3beta-hydroxy-16-pregnen-20-one by Trichoderma viride |
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| Authors: | Liu Hong-Min Ge Wenzhong Li Heping Wu Jian |
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| Institution: | Zhengzhou University, Department of Chemistry, No. 75 Da Xue North Road, ZhengZhou, Henan 450052, China. liuhm@zzu.edu.cn |
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| Abstract: | Fermentation of 5alpha,6alpha-epoxy-3beta-hydroxy-16-pregnen-20-one (4) with Trichoderma viride under aerobic condition yielded 3beta,5alpha,6beta-trihydroxy-16-pregnen-20-one (5) and 3beta,5alpha,6beta,15beta-tetrahydroxy-16-pregnen-20-one (6). Each microbial metabolite was characterized by spectroscopic methods. Compounds 6 and 3beta,5alpha,15beta-trihydroxy-16-pregnen-6,20-dione (7) are reported for the first time. |
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