Use of genetic markers to certify fetal origin of cultured amniotic fluid cells |
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| Authors: | Shi-Han Chen L. E. Karp C. R. Scott W. Chen |
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| Affiliation: | (1) Center for Inherited Diseases, University of Washington, Seattle, WA, USA;(2) Department of Pediatrics, University of Washington, Seattle, WA, USA;(3) Center for Inherited Diseases, University of Washington, Seattle, WA, USA;(4) Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA |
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| Abstract: | Summary Phenotypes of five polymorphic enzymes: red cell acid phosphatase, phosphoglucomutase, esterase D, adenosine deaminase, and 6-phosphogluconate dehydrogenase were determined in extracts of 24 amniotic fluid cell cultures and in the corresponding maternal red cells. Twenty-one of the 24 fetus/mother pairs can be distinguished by at least one of the markers. Thus, polymorphic enzyme markers may be useful in affirmation of fetal origin of cultured cells and to avoid possible diagnostic errors.Work supported by USPHS grants GM 15253 and AI 12617 |
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