Effects of prostacyclin (PGI2) and indomethacin on neonatal lamb mesenteric and renal artery responses to electrical stimulation and norepinephrine |
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| Authors: | Steven M Yabek Barry P Avner |
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| Institution: | Departments of Pediatrics and Pharmacology, University of New Mexico, School of Medicine, Albuquerque, New Mexico, USA |
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| Abstract: | The effects of prostacyclin (PGI2) and indomethacin on isolated neonatal lamb mesenteric and renal artery responses to electrical stimulation and injected norepinephrine were investigated. PGI2 (1μM) decreased baseline tension and significantly reduced vasoconstrictor responses to electrical stimulation and norepinephrine. Indomethacin raised baseline tension and potentiated the constrictor responses. PGI2 reversed completely the potentiating effects of indomethacin. These results suggest that PGI2 may modulate the responses to adrenergic stimuli in the mesenteric and renal arteries of neonatal lambs. |
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| Keywords: | Correspondence to: Steven M Yabek M D Department of Pediatrics University of New Mexico School of Medicine Albuquerque New Mexico 87131 USA |
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