THE INFLUENCE of A LOW ENVIRONMENTAL TEMPERATURE ON the STEM CELL POPULATION of the BONE MARROW and INTESTINAL MUCOSA |
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| Authors: | D. G. Baker, A. L. Carsten &dagger ,A. F. Hopper &Dagger |
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| Affiliation: | Research Carried Out At Brookhaven National Laboratory Under the Auspices of the U.S. Atomic Energy Commission |
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| Abstract: | Protracted exposure of rats to a low environmental temperature (2° C) resulted in almost a two-fold increase in the number of colony forming units per femur. Following a dose of Vinblastine, return of CFUs in the bone marrow to the pretreatment level was more rapid in the cold exposed rats than in rats at a 25° C environment. the cell cycle time of the cells in the intestinal crypt was reduced for the cold exposed rats. These observations are thought to be the basis for the increased radioresistance and/or more rapid recovery from whole body irradiation previously reported. |
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