HEMOPOIETIC STEM CELL PROLIFERATION AND MIGRATION FOLLOWING BORDETELLA PERTUSSIS VACCINE |
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| Authors: | Francis C Monette Bernard S Morse Donald Howard Eero Niskanen Frederick Stohlman Jr |
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| Institution: | Department of Medicine and Research, St Elizabeth's Hospital of Boston, Tufts University School of Medicine, Boston, Massachusetts |
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| Abstract: | The ability of a single injection of killed, intact bacteria to effect an increase in the proliferative rate of hemopoietic stem cells was studied. The total numbers of colony forming units in bone marrow, spleen and peripheral blood as well as the proportion of CFU in cycle was assessed. Splenic CFU were observed to rise exponentially due initially to in situ proliferation and later to proliferation in bone marrow with migration via the blood to the spleen. The results are discussed in the light of current concepts of stem cell regulation. |
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