Protein kinase C promotes the phosphorylation of immunoprecipitated middle T antigen from polyoma-transformed cells |
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Authors: | L Raptis A L Boynton J F Whitfield |
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Abstract: | Stimulation of protein kinase C in polyoma virus-transformed cells increased the phosphorylation of tyrosine residues of the viral middle T (mT) antigen in mT:pp60c-src complexes precipitated by anti-mT antibodies. This increase might have been due to a stimulation of the complex's pp60c-src tyrosine kinase activity or to an increased ability of the mT protein to be phosphorylated by pp60c-src. These observations suggest that cellular protein kinase C might control the ability of polyoma virus to transform its host cell. |
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