Genetic determinants of hepatic steatosis in man |
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| Authors: | Hooper Amanda J Adams Leon A Burnett John R |
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| Affiliation: | *Department of Core Clinical Pathology and Biochemistry,*Royal Perth Hospital, Perth, Australia;†Schools of Medicine and Pharmacology University of Western Australia, Perth, Australia;§Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia;**Department of Gastroenterology and Hepatology, Sir Charles Gairdner Hospital, Perth, Australia |
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| Abstract: | Hepatic steatosis is one of the most common liver disorders in the general population. The main cause of hepatic steatosis is nonalcoholic fatty liver disease (NAFLD), representing the hepatic component of the metabolic syndrome, which is characterized by type 2 diabetes, obesity, and dyslipidemia. Insulin resistance and excess adiposity are considered to play key roles in the pathogenesis of NAFLD. Although the risk factors for NAFLD are well established, the genetic basis of hepatic steatosis is largely unknown. Here we review recent progress on genomic variants and their association with hepatic steatosis and discuss the potential impact of these genetic studies on clinical practice. Identifying the genetic determinants of hepatic steatosis will lead to a better understanding of the pathogenesis and progression of NAFLD. |
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| Keywords: | alcoholic fatty liver disease cirrhosis fibrosis genetic factors gene variants nonalcoholic fatty liver disease nonalcoholic steatohepatitis single nucleotide polymorphisms susceptibility |
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